Dr. Abhinand CS

Scientist C

Dr. Abhinand CS earned his PhD in Computational Biology and Bioinformatics from the University of Kerala, India. He gained postdoctoral experience in mass spectrometry-based proteomics at the Institute for Advanced Biosciences (IAB), Keio University, Japan. Subsequently, he served as a scientist in the Department of Computational Biology and Bioinformatics at the University of Kerala, where he focused on viral informatics studies related to emerging viruses. In 2022, he joined the Center for Systems Biology and Molecular Medicine at Yenepoya University as an Assistant Professor, where he investigated host-pathogen interactions associated with EBV, NiV, and SARS-CoV-2. At present, he is working as a Scientist C at the Institute of Advanced Virology, focusing on elucidating viral entry mechanisms of emerging viruses using machine learning-based approaches and developing new druggable candidates through AI-based drug discovery.

Academic Positions

2024-present: Scientist C

Institute of Advanced Virology, Trivandrum

2022-2024: Assistant Professor

CSBMM, Yenepoya (Deemed to be University), Mangalore

2020-2022: Scientist

Department of Computational Biology & Bioinformatics, University of Kerala, Trivandrum

2019-2020: DBT-BIF Fellow

Department of Computational Biology & Bioinformatics, University of Kerala, Trivandrum

2017-2018: Post-Doctoral Fellow

Keio Institute for Advanced Biosciences, Japan

Education

2017: PhD Computational Biology and Bioinformatics-University of Kerala

2013: Mphil Bioinformatics-University of Kerala

2010: MSc Bioinformatics-University of Kerala

Scientific discipline

Multi-omics, Bioinformatics, Artificial Intelligence and Machine Learning, Data Science

Awards

2024

Teachers Associateship for Research Excellence (TARE) award, SERB, Govt. of India

2017

Kuraray/Leave a Nest Grant Runner-up award

2015

Travel Grant award, SIUCEB, Govt. of Kerala

2014

International Travel Grant, VirginiaTech, USA

2013

Best poster award, International Conference on “Tropical Roots and Tubers for Sustainable Livelihood under Changing Agro-climate”

2012

Research fellowship award, KSCSTE, Govt. of Kerala

Contact

Research summary

Understanding the receptors and molecular pathways that facilitate viral entry into human cells is crucial for developing novel therapeutic approaches. Computational methods offer a powerful platform for identifying host-pathogen interactions by using sequence- and structure-based data. The major focus of the lab is to develop machine-learning models for predicting viral entry receptors and other human interactomes. Through this, the lab aims to uncover both common and virus-specific receptors, as well as the molecular pathways viruses use to invade host cells. We also interest in capturing virus-induced host responses using the data generated from advanced techniques such as high-throughput sequencing and mass spectrometry, and converting it into a public repository. Besides, the lab has a strong interest in identifying antiviral compounds through drug repurposing and AI-driven drug design, with the goal of contributing to the discovery of effective therapeutic solutions for combating viral infections

Current Research Grants

2025-2028

Decoding interactions of dengue virus proteins with human ion channels for alternative therapeutic strategies and drug repurposing using machine learning based approach. ANRF—Prime Minister’s Early Career Research Grant Scheme

2023-2026

Osteogenesis Imperfecta: Quest for molecular curative strategies for detection and informed therapy. (Co-PI). Indian Council of Medical Research (ICMR)

Mahin, A., Soman, S. P., Modi, P. K., Raju, R., Keshava Prasad, T. S., & Abhinand, C. S. (2024). Meta-analysis of the serum/plasma proteome identifies significant associations between COVID-19 with Alzheimer’s/Parkinson’s diseases. Journal of neurovirology, 30(1), 57–70. https://doi.org/10.1007/s13365-023-01191-7

Krishnan, D., Babu, S., Raju, R., Veettil, M. V., Prasad, T. S. K., & Abhinand, C. S. (2024). Epstein-Barr Virus: Human Interactome Reveals New Molecular Insights into Viral Pathogenesis for Potential Therapeutics and Antiviral Drug Discovery. Omics : a journal of integrative biology, 28(1), 32–44. https://doi.org/10.1089/omi.2023.0241

Hemavathi, K. N., Middha, S. K., Raju, R., Pilankatta, R., Keshava Prasad, T. S., & Abhinand, C. S. (2024). Computational screening of phytocompounds from C.amboinicus identifies potential inhibitors of influenza A (H3N2) virus by targeting hemagglutinin. Journal of biomolecular structure & dynamics, 1–13. Advance online publication. https://doi.org/10.1080/07391102.2024.2424940

Mahin, A., Chikmagalur Ravindra, S., Ramesh, P., Naik, P., Raju, R., Keshava Prasad, T. S., & Abhinand, C. S. (2024). Unveiling Actin Cytoskeleton Role in Mediating Chikungunya-Associated Arthritis: An Integrative Proteome-Metabolome Study. Vector borne and zoonotic diseases (Larchmont, N.Y.), 24(11), 753–762. https://doi.org/10.1089/vbz.2024.0018

Hemavathi, K. N., Skariyachan, S., Raju, R., Keshava Prasad, T. S., & Abhinand, C. S. (2024). Computational screening of potential anti-inflammatory leads from Jeevaneeya Rasayana plants targeting COX-2 and 5- LOX by molecular docking and dynamic simulation approaches. Computers in biology and medicine, 171, 108164. https://doi.org/10.1016/j.compbiomed.2024.108164

Kumari, P., Abhinand, C. S., Kumari, R., Upadhyay, A., & Satheeshkumar, P. K. (2024). Design, development and characterization of a chimeric protein with disulfide reductase and protease domain showing keratinase activity. International journal of biological macromolecules, 278(Pt 4), 135025. https://doi.org/10.1016/j.ijbiomac.2024.135025

Banjan, B., Vishwakarma, R., Ramakrishnan, K., Dev, R. R., Kalath, H., Kumar, P., Soman, S., Raju, R., Revikumar, A., Rehman, N., & Abhinand, C. S. (2024). Targeting AFP-RARβ complex formation: a potential strategy for treating AFP-positive hepatocellular carcinoma. Molecular diversity, 10.1007/s11030-024-10915-8. Advance online publication. https://doi.org/10.1007/s11030-024-10915-8

Banjan, B., Raju, R., Keshava Prasad, T. S., & Abhinand, C. S. (2024). Computational identification of potential bioactive compounds from Triphala against alcoholic liver injury by targeting alcohol dehydrogenase. Molecular diversity, 10.1007/s11030-024-10879-9. Advance online publication. https://doi.org/10.1007/s11030-024-10879-9

Abhinand, C. S., Prabhakaran, A. A., Krishnamurthy, A., Raju, R., Keshava Prasad, T. S., Nair, A. S., Rajasekharan, K. N., Oommen, O. V., & Sudhakaran, P. R. (2023). SARS-CoV-2 variants infectivity prediction and therapeutic peptide design using computational approaches. Journal of biomolecular structure & dynamics, 41(20), 11166–11177. https://doi.org/10.1080/07391102.2022.2160819

Abhinand, C. S., Prabhakaran, A. A., Krishnamurthy, A., Raju, R., Keshava Prasad, T. S., Nair, A. S., Rajasekharan, K. N., Oommen, O. V., & Sudhakaran, P. R. (2023). SARS-CoV-2 variants infectivity prediction and therapeutic peptide design using computational approaches. Journal of biomolecular structure & dynamics, 41(20), 11166–11177. https://doi.org/10.1080/07391102.2022.2160819

Abhinand, C. S., Ibrahim, J., Keshava Prasad, T. S., Raju, R., Oommen, O. V., & Nair, A. S. (2023). Molecular docking and dynamics studies for the identification of Nipah virus glycoprotein inhibitors from Indian medicinal plants. Journal of biomolecular structure & dynamics, 41(19), 9211–9218. https://doi.org/10.1080/07391102.2022.2153169

Abhinand, C. S., Nair, A. S., Krishnamurthy, A., Oommen, O. V., & Sudhakaran, P. R. (2022). Potential protease inhibitors and their combinations to block SARS-CoV-2. Journal of biomolecular structure & dynamics, 40(2), 903–917. https://doi.org/10.1080/07391102.2020.1819881

Abhinand, C. S., Galipon, J., Mori, M., Ramesh, P., Prasad, T. S. K., Raju, R., Sudhakaran, P. R., & Tomita, M. (2023). Temporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: an insight into early signaling events associated with angiogenesis. Journal of cell communication and signaling, 17(3), 1067–1079. https://doi.org/10.1007/s12079-023-00736-z

Abhinand, C. S., Athira, P. A., Soumya, S. J., & Sudhakaran, P. R. (2020). Multiple Targets Directed Multiple Ligands: An In Silico and In Vitro Approach to Evaluating the Effect of Triphala on Angiogenesis. Biomolecules, 10(2), 177. https://doi.org/10.3390/biom10020177

Abhinand, C. S., Raju, R., Soumya, S. J., Arya, P. S., & Sudhakaran, P. R. (2016). VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis. Journal of cell communication and signaling, 10(4), 347–354. https://doi.org/10.1007/s12079-016-0352-8

Selected Publications

Team

Team Members

Ms. Devika Raj

Project Associate

devikaraj2506@gmail.com

Mr. Jagannath R S

Ph.D. Scholar

jj.jagannathrs@d1.iav.res.in

Ms. Parvathy Suresh

JRF

parusureshpkd@gmail.com

Dr.Arya K.R

Project Scientist

aaryakr@d1.iav.res.in

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