Most of the emerging infections begin with acute fever and overlapping symptoms that are difficult to distinguish clinically. The current approach of testing for individual diseases based solely on clinical suspicion leads to missing of many causative organisms, especially those that are newly introduced. Also, with increase in air travel, introduction of exotic disease that are not reported from the country are highly possible. This demand development of diagnostic kits with an expanded spectrum of detection, incorporating targets for those pathogens that have a high likelihood of exotic introduction. Development of multiplex kits that uses a syndromic approach with inclusion of diagnostic targets of viruses affecting an organ system, such as respiratory, enteric or nervous system, and others will make them more clinician friendly. Coupling amplification technology to microarray technology in newer diagnostic approaches are under fast development elsewhere. This helps to overcome the limitation of current real-time PCR-based approaches that can detect only up to six targets including internal control, even in the most advanced systems. In the plan proposal, we intend to develop array hybridisation chips or systems that can look for multiple pathogens, in a syndromic diagnostic approach indigenously.